The Origin of Reverse-aging
IKK-β links inflammation to obesity-induced insulin resistance - Nature Medicine
Nuclear factor-κB in cancer development and progression - Nature
A Malignant Flame : Understanding chronic inflammation, which contributes to heart disease, Alzheimer's and a variety of other ailments, may be a key to unlocking the mysteries of cancer - Scientific American
Now, scientists around the world start to carefully talk about the possibility of anti-aging drugs. – Fortune
Neuro-inflammation is one of the major causes of the brain disorders.
The degenerative disease is closely related to the chronic inflammation.
Over the last decade, an increasing amount of medical research has focused on the role of inflammation in aging and disease. Certain conditions, such as asthma, allergies, arthritis, and auto-immune disorders, have an obvious inflammatory component. However, chronic, low-level inflammation (sometimes referred to as “systemic” or “silent” inflammation) has now been linked with diseases ranging from heart disease, diabetes, and cancer to depression, Alzheimer’s, and osteoporosis. Inflammation also appears to be a key factor in skin aging and other outward signs of aging.
Anti-inflammation effect of Botamedi marine bio-phenol
Effective reduction of NF-kB without side-effect
NF-kB as biomarker of inflammation
*. New study underscores NF-kB in aging
A new study underscores the potential role of the NF-kB protein in aging. NF-kB is a master protein which controls many inflammatory chemicals throughout the body. Researchers have studied NF-kB for many years as a potential way of controlling chronic inflammation which accompanies aging and underlies conditions such as Alzheimer’s disease. This new study points to a part of the brain as regulating the aging process. The current view of aging generally suggests that enzymes, DNA, proteins and other constituents of the body essentially “wear out” with age, accumulating damage due to environmental insults until they no longer function properly. This new study suggests something quite different, namely that a part of the brain called the Hypothalamus deliberately induces aging throughout the body. It has been suggested that one reason why the brain might take such drastic action is to inhibit reproduction past a certain age.
The data offered by the researchers suggests that, with age, increased NF-kB activity triggers degeneration in both the brain and other areas of the body. The researchers showed that as mice aged, they increasingly expressed NF-kB in the part of the brain that is normally responsible for the production of reproductive and growth hormones. The researchers artificially manipulated NF-kB activity using genetic techniques and showed that reducing NF-kB activity was associated with better performance in cognitive tests, greater muscle strength and greater bone mass and skin thickness. Conversely, exacerbation of NF-kB activity increased all of these peripheral signs of aging, as well as reducing cognitive abilities. Furthermore the research suggested that microglia (the inflammatory cells resident in the brain) are the originators of the NF-kB activity and this spreads to nearby neurons, including those responsible for growth and reproductive hormones.
These findings are of direct significance that increased NF-kB collates strongly with Alzheimer’s pathology and pathology of other central nervous system disorders.
Anti-inflammation may overcome the chronic disease.
Chronic inflammation contributes to Alzheimer's, Cancer, ...